| Title | [Anti-HLA antibody detection and refection in renal transplantation: impact of the new technologies] | | Author(s) | Georgescu D, Ferrari-Lacraz S, Villard J | | Institution | Unité d'immunologie de transplantation, Service d'allergologie et immunologie, HUG, Genève. | | Source | Rev Med Suisse 2007 Apr 25; 3(108):1064-9. | | Abstract | In kidney transplantation, hyperacute rejection is mediated by anti-HLA antibody which are also responsible for antibody-mediated acute rejection. In addition anti-HLA antibody are also implicated in the physiopathological mechanism of chronic rejection. The gold standard methodology to detect anti-HLA antibody is based on the complement-dependant-cytotoxicity. This technic is neither specific nor sensitive. New powerful technologies, which are specific and very sensitive, have been developed like Elisa and flow cytometer with fluorescent micro-beads to detect anti-HLA antibody. In this article, we review the importance of anti-HLA antibody in humoral rejection. We also discussed the clinical relevance of the detection of anti-HLA antibody by these new approaches. | | Language | fre | | Pub Type(s) | English Abstract
Journal Article
| | PubMed ID | 17552259 |
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